Anesthesiology!

[dr_maria]

Which statement regarding local anesthetics is true?

a. When used for infiltration anesthesia,the maximal safe total dose of
lidocaine is 3.0 mg per kilogram of body weight.

b. Addition of epinephrine (1:200,000)to the solution of lidocaine, procaine,
or bupivacaine does not increase the maximal safe total dose but increases
the duration of the block.

c. Numerous individuals are hypersensitive to local anesthetics.

d. A local anesthetic in contact with a nerve trunk will cause sensory loss
but not motor paralysis in the area innervated.

e. Rapid systemic administration of local anesthetics may produce death

without signs of CNS stimulation.

[dr_maria]

Answer is e !!!

Rapid systemic administration of local anesthetics may produce death without signs of CNS stimulation.

[dr_maria]

The maximal safe total dose of lidocaine administered to a 70-kg man is 4.5 mg/kg, or approximately 30–35 mL of a 1% solution.

The addition of epinephrine to lidocaine,procaine, or bupivacaine not only doubles the duration of infiltration
anesthesia, but increases by one-third the maximal safe total dose by decreasing the rate of absorption of drug into the bloodstream.

Epinephrine-containing solutions should not, however, be injected into tissues supplied by end arteries (e.g., fingers, toes, ears, nose, penis).

Hypersensitivity to local anesthetics is uncommon and occurs most prominently with anesthetics of the ester type (procaine, tetracaine).