mark wrote:
Quote:
12. An increase in 2, 3 diphosphogylcerate concentration in red blood cells:
a. increases the oxygen consumption of the cells
b. occurs during storage
c. shifts the oxyhaemoglobin dissociation curve in the same direction as hypothermia
d. shifts the oxyhaemoglobin dissociation curve in the same direction as acidaemia
e. occurs in chronic hypoxamia
|
a F b F c F d T e T
2,4 diphosphoglyerate is produced by a side shunt from glycolysis and is present in large amounts in red blood cells. It binds with the beta chain of haemoglobin, changing the protein conformation and reducing the oxygen affinity, and facilitating off loading of oxygen to the tissues. 2,3 dpg therfore shifts the ODC to the right; levels are increased by anaemia and exposure to high altitude. Stored blood has reduced levels of 2,3 dpg.
Linear Mode
