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Anaesthesia Site Editor
Prime Minister Rank
Posts: 1,741
Join Date: Mar 2005
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21) CONCERNING THE TRANSMITTER AT MOTOR NERVE TERM -
03-29-2005, 06:41 AM
a) it is formed from choline and acetyl co enzyme A
b) formation occurs in the cleft
c) it is broken down by pseudo cholinesterase
d) it has a muscurinic action
e) release is increased by botulinum toxins
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Anaesthesia Site Editor
Prime Minister Rank
Posts: 1,741
Join Date: Mar 2005
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Re:21) CONCERNING THE TRANSMITTER AT MOTOR NERVE TERM -
03-29-2005, 06:41 AM
TFFFF
Acetylcholine Is produced within the distal end of the motor neurone. It is formed by the action of acetyl coenzyme A choline and choline acetyl transferase. It is stored in vesicles and its release is dependent upon an action potential mediated opening of voltage gated calcium channels.
Once within the cleft it is broken down by acetylsholinesterase. Its action is on cholinergic receptors on the muscle cell. It is however an agonist at muscurinic receptors but not at the motor nerve terminal.
Botulism toxin is a non competitive antagonist at this receptor resulting in paralysis.
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