27) WHICH OF THE FOLLOWING ARE SEEN FOLLOWING TOTA

[Editor]

27) WHICH OF THE FOLLOWING ARE SEEN FOLLOWING TOTAL PANCREATECTOMY

a) No change in plasma insulin level
b) No change in plasma glucagon level
c) steatorrhoea
d) increased plasma levels in free fatty acids
e) decreased plasma paco2

[Editor]

FFFTT

The pancreas has 4 cell types:
Alpha: 25% of cells. Secretes glucagons
Beta : 70%. Secrete insulin
Delta: 5%.secrete somatostatin
F cells: secrete pancreatic polypeptide.
The removal of the pancreas can be considered to mimic clinical conditions such as diabetes mellitus. Due to the lack of the effect of insulin an effective state of cellular starvation would occur. Despite hyperglycaemia the cells would have little glucose and undergo anaerobic metabolism. The result would be the initiation of a catabolic state in order to provide these cells with fuel. Protein and fat catabolism would hence occur.
Steatorrhoea would not occur as long as biliary secretion into the gut was unaltered.
Due to the altered substrate usage the respiratory quotient would change. The RQ’s are:
Carbohydrate 1.0
Fat 0.7
Protein 0.8
Respiratory quotient = co2 production /oxygen utilization.