mark wrote:
Quote:
2. The GFR is lowered by
a) a higher ECF volume
b) urethal obstruction
c) a higher ADH cocnentration
d) a higher plasma urea concentration
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a.f
b.f
c.t
d.f.
GFR, is affected by
a) renal blood flow, and capillary vascular tone
b)ureteric obstruction
c) renal oedema
It depends on,
1)effective glomerular surface area,which is reduce by contraction of mesengial cells with in the glomerulus:in responseto angiotensin ii,vasopressin, noradrenalin, histamine, prostaglandins.
Dopamine and ANP relaxes it.
2)permeability of capillary wall, basement membrane, glomerular epitheliium:
depends on size (4-8nm), protein binding, charge of substance filtered.
3)hydrostatic gradient across the capillery walls.