11) .CLEARANCE

[Editor]

a) is calculated by the volume per unit time T
b) is calculated by the mass per unit time (?)
c) is inversely related to a drugs half life T
d) is dependent on liver metabolism T
e) is independent of the volume of distribution F

[Editor]

tt?ft
Clearance is volume of plasma cleared of a drug per unit time; more the clearance less the half life. Hepatic metabolism will affect hepatic clearance. Hepatic clearance
= ER . HBF. Total clearance= CLr + CL h+ CLx. Volume of distribution will affect the clearance inversely. Eg. Fentanyl Vd more than alfentanyl, so cleared less.

[jijindr]

unit of clearance is ml/kg/min. so b)false