102) HEPATIC BLOOD FLOW

[Editor]

a) is affected by IPPV
b) is reduced by halothane
c) is increased by ketamine
d) is mainly centrilobular
e) is mainly venous

[Editor]

T
T also enflurane
F no change all others reduce
-
T only 30 hepatic artery

[sangram]

d- centriacinar, not centrilobular.

[drvp]

->Artificial ventilation decreases liver blood flow significantly primarily by reducing cardiac output and simultaneously increasing hepatic outflow resistance, frequently associated with controlled ventilation, particularly when high positive end-expiratory pressures is applied.
->Of the volatile anaesthetics, total hepatic blood flow is usually well maintained during anaesthesia with isoflurane , despite the fact that isoflurane has similar effects on the portal circulation as halothane and enflurane.
->Most intravenous anaesthetics and analgesics seem to have no direct effects on the liver circulation. However, reductions in cardiac output or arterial pressure that are frequently associated with the use of these agents may cause secondary decreases of portal venous and/or hepatic arterial blood flow. Ketamine may cause no change or slightly increase liver blood flow.

[Ref : http://www.euroanesthesia.org/educat...enna/04rc1.HTM ]